Beilstein J. Org. Chem.2023,19, 133–138, doi:10.3762/bjoc.19.13
, Japan 10.3762/bjoc.19.13 Abstract A new antibacterial 3-monoacyl-sn-glycerol, nostochopcerol (1), was isolated from a cultured algal mass of the edible cyanobacterium Nostochopsislobatus MAC0804NAN. The structure of compound 1 was established by the analysis of NMR and MS data while its chirality was
established by comparison of optical rotation values with synthetically prepared authentics. Compound 1 inhibited the growth of Bacillus subtilis and Staphylococcus aureus at MIC of 50 μg/mL and 100 μg/mL, respectively.
Keywords: antibacterial; cyanobacterium; edible; monoacylglycerol; Nostochopsislobatus
limited number of attempts include an antifungal lipopeptide nostofungicidine [4] and an antioxidant nostocionone [5] from Nostoc commune, an unusual antibacterial n−1 fatty acid from N. verrucosum [2], and the sacrolides, antimicrobial oxylipin macrolactones from Aphanothece sacrum [6][7].
Nostochopsis
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Graphical Abstract
Figure 1:
Structure of nostochopcerol (1) and selected COSY (bold lines) and HMBC (arrows) correlations.